Figure 1: Unsupervised hierarchical clustering of significant genes.
From: Testis Transcriptome Modulation in Klinefelter Patients with Hypospermatogenesis
The heatmap shows the differential expression of the 1050 significantly expressed genes in mosaic KS testis vs. control testis, grouped in two different clusters composed respectively by 747 down-regulated genes (Cluster A) and 303 up-regulated transcripts (Cluster B). The top tree represents the 6 experiments (3 patients run as a duplicate dye-swap). Each patient RNA was analysed against the control RNA (pool of RNA from three control subjects). In green the genes showing negative expression, in red the genes showing positive expression. Black and grey represent respectively missing and not significant changes in expression.
