Figure 3: IPA-inferred top-scored networks associated to cluster A and B gene datasets.
From: Testis Transcriptome Modulation in Klinefelter Patients with Hypospermatogenesis
IPA-inferred network analysis was generated for clusters A and B transcripts linking genes functionality to disclose mechanistic networks based on their connectivity and enrichment statistics. (A) Top gene network generated by IPA for Cluster A. The network is centred around the key node genes CUL2 and CALM1, involved in pathways that regulate the communications between germ and Sertoli cells. (B) Top gene network generated by IPA for Cluster B. The network shows the involvement of FGFs and NFKb pathways in increased testicular apoptosis. In light grey the genes down-regulated listed in cluster A, in dark grey the genes up-regulated listed in cluster B. White genes are transcripts not modulated in our series.
