Figure 4: IPA-inferred second-scored networks associated to cluster A and B gene datasets.
From: Testis Transcriptome Modulation in Klinefelter Patients with Hypospermatogenesis
(A) Second-scored gene network generated by IPA for Cluster A. The network is centred around the key node CREM, main testicular transcription factor essential to spermatozoa production. (B) Second-scored gene network generated by IPA for Cluster B. The network shows the presence of transcripts causing increased inflammation and necrosis processes. In light grey the genes down-regulated listed in cluster A, in dark grey the genes up-regulated listed in cluster B. White genes are transcripts not modulated in our series.
