Figure 3: Typical activation features arising from CAM IS to AS-L transitions.
From: Structural heterogeneity of the μ-opioid receptor’s conformational ensemble in the apo state
(a) The toggle switch (blue) rotation concerts with the opening of the hydrophobic barrier (yellow dots) and formation of the water channel upon activation. Water molecules inside the channel are shown in red spheres. Blue dashed lines indicate hydrogen bonds. (b) Rearrangements of V2826.37, M1613.46 and Y3367.53 upon activation: Y3367.53 interacts with M1613.46 and V2826.37 is released. This latter interaction is monitored here by the minimal sidechain distance between M1613.46 and V2826.37 (Fig. S4b).
