Table 1 Selected differences between the CAM and the WT (mean ± standard deviation are given when applicable).
From: Structural heterogeneity of the μ-opioid receptor’s conformational ensemble in the apo state
CAM | WT | |
|---|---|---|
Allosteric Na+ ion lifetime | 2% | 18% |
W2936.48 sidechain orientation (χ2 dihedral angle) | IS: −74.3 ± 11.4 | 73.2 ± 16.2 |
I1553.40 sidechain orientation (χ1 dihedral angle) | IS: −60.4 ± 5.8 | −59.9 ± 8.0 |
P2445.50-F2896.44 minimal sidechain distance | IS: 5.8 ± 0.9 | 6.5 ± 0.4 |
Number of “core” residues (see “Methods”) | 50 | 65 |
Intramolecular community network | CAM shows weaker coupling around the mutation site, in the upper half of TM3 and the lower half of TM7 than the WT | |
