Table 1 Type I functional divergence (FD) of α-glucosidase family of insect.

From: Molecular evolutionary mechanisms driving functional diversification of α-glucosidase in Lepidoptera

FD

Subfamilies

Coefficient θ ± SE (P)

Critical Amino Acid sites

TypeI FD

SUH vs. LMal

0.3232 ± 0.0577 (P < 0.01)

101, 137, 164, 180, 212 , 230, 232, 237, 250, 269, 279, 281, 284, 288, 292, 296, 300, 307, 325, 326, 329, 330, 331, 332, 345, 350, 360, 366, 368, 369, 397, 398, 415, 503

 

SUH vs. DMal

0.3935 ± 0.0630 (P < 0.01)

141, 150, 154, 161, 165, 191 , 212 , 222*, 237, 269, 281, 295, 329, 330, 332, 345, 350, 360, 362*, 363, 364, 365, 366*, 370*, 373*, 374, 405, 415, 458, 468

 

LMal vs. DMal

0.1980 ± 0.0516 (P < 0.01)

148, 150*, 165, 229, 247, 265, 321, 362*, 365*, 369*, 370*, 373, 374, 398, 402, 454, 483

 

SUH vs. Mal

0.2826 ± 0.0549 (P < 0.01)

101, 154, 161, 212 , 222, 237, 269, 281, 284, 295, 296, 325, 326, 329, 330, 331, 332, 345, 350*, 360, 362, 364, 366, 368, 373, 374, 415, 458

 

SUH1 vs. SUH2

−0.4862 ± 0.023

287*, 380*, 393*, 496*

  1. Functional divergences (Coefficient θ) for pairwise comparisons within the α-glucosidase family of insect are shown as value ± standard error. Critical amino acid sites detected as relating to FD with P > 70% (>90%, indicated with asterisks) are listed. Numbering refers to the positions in the alignments of protein sequences generated by MAFFT alignment. Residues that also under positive selection and relative to ligand-binding are presented by bold and underline, respectively.
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