Figure 2: Knockdown of GPR91 expression attenuated pathological alterations in retinal vessels in OIR rats.
From: Transcription factors regulate GPR91-mediated expression of VEGF in hypoxia-induced retinopathy
(A) Fluorescein-dextran images of the retinal vessels in P14 rat retinas from each group. White dashed lines indicate the boundaries of blood vessels. (B) ADPase staining of peripheral retinas in P18 rats from each group. White arrows denote abnormal neovascularization tufts. (C) Immunohistochemical analyses of trypsin-digested retinal blood vessels in P14 rat retinas from each group. Black arrows denote the loss of pericytes. (D) Quantitative analysis of the number of acellular capillaries per mm2. (E) Quantitative analysis of the ratio of endothelial cells to pericytes. Each column denotes the mean ± SD (n = 6). **P < 0.01 versus RA group rats. ##P < 0.01 versus LV.shScrambled group rats.
