Table 3 Network meta-analysis results for UPDRS II, UPDRS III, UPDRS total represented by mean difference (MD) and 95% credible interval (CrI), withdrawals represented by odds ratio (OR) and 95% CrI. In lower half of the table, row treatments are compared against column treatments, whereas in the upper half, column treatments are compared against row treatments.
UPDRS III | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Treatment | Placebo | Bromocriptine | Cabergoline | Lazabemide | Levodopa | Pergolide | Pramipexole | Rasagiline | Ropinirole | Rotigotine | Selegiline | |
Placebo | Placebo | −3.18 (−5.91, −0.44) | −3.64 (−8.70, 1.33) | 0.85 (−3.04, 4.56) | −4.33 (−6.85, −1.83) | 0.11 (−5.15, 5.19) | −4.38 (−6.09, −2.67) | −2.06 (−5.06, 0.79) | −4.05 (−6.08, −2.04) | −3.09 (−5.37, −0.79) | −4.15 (−6.63, −1.70) | |
Bromocriptine | −0.74 (−2.26, 0.78) | Bromocriptine | −0.47 (−5.13, 4.17) | 4.04 (−0.78, 8.66) | −1.16 (−4.35, 1.98) | 3.30 (−2.39, 8.82) | −1.19 (−4.20, 1.74) | 1.10 (−2.91, 5.08) | −0.87 (−3.41, 1.64) | 0.13 (−3.49, 3.57) | −0.97 (−4.49, 2.54) | |
Cabergoline | −1.42 (−3.74, 0.84) | −0.66 (−2.80, 1.39) | Cabergoline | 4.48 (−1.86, 10.89) | −0.67 (−5.74, 4.39) | 3.72 (−3.05, 10.63) | −0.74 (−5.92, 4.45) | 1.60 (−4.25, 7.40) | −0.40 (−5.42, 4.63) | 0.56 (−4.88, 6.05) | −0.51 (−5.93, 5.10) | |
Lazabemide | 0.80 (−0.75, 2.33) | 1.55 (−0.61, 3.74) | 2.22 (−0.53, 4.99) | Lazabemide | −5.20 (−9.77, −0.65) | −0.71 (−7.29, 5.70) | −5.25 (−9.38, −1.09) | −2.92 (−7.70, 1.83) | −4.93 (−9.21, −0.58) | −3.94 (−8.32, 0.47) | −5.00 (−9.53, −0.36) | |
Levodopa | −1.62 (−2.74, −0.49) | −0.87 (−2.54, 0.78) | −0.20 (−2.43, 2.03) | −2.43 (−4.33, −0.50) | Levodopa | 4.45 (−0.17, 8.91) | −0.04 (−2.55, 2.41) | 2.25 (−1.60, 6.14) | 0.28 (−2.45, 2.96) | 1.30 (−2.09, 4.57) | 0.18 (−3.08, 3.53) | |
UPDRS II | Pergolide | 0.17 (−1.90, 2.34) | 0.92 (−1.51, 3.37) | 1.60 (−1.23, 4.45) | −0.62 (−3.22, 2.02) | 1.79 (0.01, 3.63) | Pergolide | −4.50 (−9.56, 0.82) | −2.18 (−8.17, 3.83) | −4.19 (−9.44, 1.24) | −3.18 (−8.73, 2.49) | −4.24 (−9.81, 1.49) |
Pramipexole | −1.60 (−2.33, −0.87) | −0.84 (−2.45, 0.71) | −0.18 (−2.46, 2.14) | −2.40 (−4.09, −0.66) | 0.03 (−1.11, 1.17) | −1.77 (−3.92, 0.38) | Pramipexole | 2.33 (−1.16, 5.63) | 0.32 (−2.06, 2.73) | 1.31 (−1.44, 4.03) | 0.25 (−2.72, 3.17) | |
Rasagiline | −0.42 (−1.69, 0.88) | 0.33 (−1.67, 2.28) | 1.02 (−1.67, 3.63) | −1.21 (−3.23, 0.79) | 1.20 (−0.50, 2.88) | −0.58 (−3.15, 1.88) | 1.18 (−0.30, 2.67) | Rasagiline | −2.02 (−5.61, 1.64) | −1.04 (−4.60, 2.78) | −2.10 (−5.83, 1.80) | |
Ropinirole | −1.69 (−2.72, −0.67) | −0.93 (−2.74, 0.80) | −0.26 (−2.74, 2.19) | −2.50 (−4.34, −0.64) | −0.08 (−1.47, 1.31) | −1.87 (−4.20, 0.39) | −0.10 (−1.34, 1.10) | −1.27 (−2.95, 0.37) | Ropinirole | 0.97 (−1.93, 3.90) | −0.10 (−3.19, 3.09) | |
Rotigotine | −1.40 (−2.35, −0.46) | −0.65 (−2.42, 1.12) | 0.02 (−2.43, 2.50) | −2.20 (−4.01, −0.40) | 0.22 (−1.24, 1.67) | −1.58 (−3.90, 0.72) | 0.18 (−0.95, 1.35) | −0.98 (−2.60, 0.61) | 0.29 (−1.03, 1.64) | Rotigotine | −1.06 (−4.39, 2.27) | |
Selegiline | −1.53 (−2.59, −0.43) | −0.77 (−2.50, 0.97) | −0.10 (−2.50, 2.36) | −2.32 (−4.20, −0.45) | 0.11 (−1.37, 1.57) | −1.70 (−4.01, 0.60) | 0.06 (−1.22, 1.38) | −1.11 (−2.76, 0.58) | 0.17 (−1.28, 1.64) | −0.11 (−1.54, 1.32) | Selegiline | |
Withdrawals | ||||||||||||
Treatment | Placebo | Bromocriptine | Cabergoline | Lazabemide | Levodopa | Pergolide | Pramipexole | Rasagiline | Ropinirole | Rotigotine | Selegiline | |
Placebo | Placebo | 1.57 (0.99, 2.45) | 1.06 (0.55, 2.11) | 0.62 (0.21, 1.93) | 0.61 (0.42, 0.92) | 1.02 (0.57, 1.88) | 1.10 (0.84, 1.46) | 0.93 (0.68, 1.29) | 0.68 (0.49, 0.97) | 0.78 (0.53, 1.13) | 1.49 (0.96, 2.39) | |
Bromocriptine | −0.36 (−10.69, 10.34) | Bromocriptine | 0.68 (0.35, 1.32) | 0.40 (0.12, 1.37) | 0.39 (0.23, 0.66) | 0.66 (0.32, 1.37) | 0.71 (0.44, 1.15) | 0.59 (0.34, 1.05) | 0.44 (0.25, 0.76) | 0.49 (0.28, 0.88) | 0.95 (0.54, 1.72) | |
UPDRS total | Cabergoline | — | — | Cabergoline | 0.59 (0.16, 2.18) | 0.58 (0.31, 1.08) | 0.97 (0.41, 2.29) | 1.04 (0.52, 2.08) | 0.87 (0.42, 1.83) | 0.64 (0.31, 1.31) | 0.73 (0.34, 1.54) | 1.40 (0.65, 3.05) |
Lazabemide | 1.78 (−5.25, 8.94) | 2.12 (−10.80, 14.80) | — | Lazabemide | 0.98 (0.30, 3.19) | 1.63 (0.46, 5.73) | 1.75 (0.56, 5.54) | 1.49 (0.46, 4.78) | 1.09 (0.34, 3.46) | 1.23 (0.38, 3.94) | 2.38 (0.72, 7.84) | |
Levodopa | −0.44 (−7.24, 6.71) | −0.11 (−10.99, 11.01) | — | −2.30 (−11.98, 8.12) | Levodopa | 1.68 (0.89, 3.15) | 1.80 (1.17, 2.75) | 1.51 (0.91, 2.51) | 1.12 (0.70, 1.75) | 1.27 (0.73, 2.14) | 2.43 (1.42, 4.23) | |
Pergolide | 8.19 (−5.83, 22.61) | 8.40 (−7.90, 25.00) | — | 6.39 (−9.76, 22.48) | 8.61 (−4.24, 21.13) | Pergolide | 1.08 (0.57, 2.03) | 0.91 (0.45, 1.77) | 0.67 (0.34, 1.28) | 0.76 (0.37, 1.51) | 1.46 (0.70, 3.07) | |
Pramipexole | −1.00 (−6.66, 5.02) | −0.70 (−11.63, 10.64) | — | −2.81 (−11.78, 6.63) | −0.54 (−6.18, 5.10) | −9.19 (−22.83, 4.50) | Pramipexole | 0.84 (0.55, 1.28) | 0.62 (0.40, 0.95) | 0.70 (0.44, 1.09) | 1.34 (0.80, 2.29) | |
Rasagiline | −2.89 (−7.66, 1.72) | −2.53 (−14.30, 8.98) | — | −4.67 (−13.32, 3.90) | −2.41 (−11.16, 5.75) | −11.01 (−26.20, 3.79) | −1.89 (−9.74, 5.32) | Rasagiline | 0.74 (0.45, 1.18) | 0.83 (0.50, 1.36) | 1.60 (0.93, 2.82) | |
Ropinirole | 2.21 (−11.78, 16.68) | 2.57 (−14.37, 19.10) | — | 0.30 (−15.37, 16.43) | 2.62 (−9.84, 14.91) | −5.98 (−23.47, 11.90) | 3.19 (−10.28, 16.71) | 5.02 (−9.67, 20.27) | Ropinirole | 1.13 (0.69, 1.82) | 2.17 (1.27, 3.84) | |
Rotigotine | — | — | — | — | — | — | — | — | — | Rotigotine | 1.93 (1.08, 3.51) | |
Selegiline | −6.04 (−11.07, −0.83) | −5.72 (−16.35, 4.83) | — | −7.77 (−16.58, 1.09) | −5.60 (−13.67, 2.23) | −14.16 (−28.85, 0.53) | −5.05 (−12.69, 2.18) | −3.11 (−10.10, 3.83) | −8.24 (−23.07, 6.30) | — | Selegiline | |
