Figure 5: Sophisticated metabolic reprogramming in HCC.

Our proteomic data revealed the up-regulation of glycolysis and pentose phosphate pathways and fatty acid biosynthesis and the down-regulation of gluconeogenesis; serine, glycine and sarcosine metabolism; and fatty acid β-oxidation. The red letters and arrows indicate up-regulated proteins and pathways, respectively, and the blue letters and arrows indicate down-regulated proteins and pathways.