Figure 5: DFS induces lysosomal-dependent FoxM1 protein degradation.

Protein levels of FoxM1 were determined by Western blot in SW480 and HCT116 cells after treatment with DFS and chloroquine (CQ) or cycloheximide (CHX) (A). Colon cancer cells were treated with DFS and the levels of E-cadherin and Notch3 were determined by Western blot assay (B).