Figure 1: The glycopatterns of serum glycoproteins from male and female HC, cHB, and ACHBLF using the lectin microarrays. | Scientific Reports

Figure 1: The glycopatterns of serum glycoproteins from male and female HC, cHB, and ACHBLF using the lectin microarrays.

From: Serum Glycopatterns as Novel Potential Biomarkers for Diagnosis of Acute-on-Chronic Hepatitis B Liver Failure

Figure 1

(A) The layout of the lectin microarray, and the binding profiles of Cy3-labeled sera proteins from HC and patients with cHB, and ACHBLF bound to the lectin microarrays. Lectins showing the difference of glycan expression levels between HC, cHB, and ACHBLF were marked with red frames. (B) Heat map and hierarchical clustering of the 37 lectins in three biological replicates. Red and green indicated up- and down-regulated glycans in the ACHBLF (ACHBLF1-3), cHB (cHB1-3) and HC (HC1-3), respectively. (C–F) Lectins revealed significant differences between HC, cHB, and ACHBLF according to one-way ANOVA (*p < 0.05, **p < 0.01, and ***p < 0.001).

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