Figure 1: The dynamic conformation of mammalian APN ectodomains.
From: Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infection
(a) Ribbon representation of the closed (pAPN), intermediate (hAPN) and open (pAPN-RBD, PDB code 4F5C) dimeric APN structures (Table 1). The APN domains colored in orange (domain I, DI), yellow (domain II, DII), red (domain III, DIII) and green (domain IV, DIV). N-linked glycans omitted. (b) Interdomain movement between the open and closed APN conformations. The arrow indicates the swing movement of the domain I-II-III module toward domain IV after ectodomain closure in each monomer of the APN dimer, with domain IV fixed by dimerization. The hinge residues at the N terminus of α13 and α15 in domain IV are marked with black dots. See also Supplementary Video S1. (c) Surface representation of the open and closed APN. Front view of the active site, with the zinc ion in domain II as a cyan sphere.
