Table 1 Cytotoxicity of PTX, TET, and PTX/TET to PTX-sensitive A2780 cells and PTX-resistant A2780/PTX cells after 48ā€‰h treatments (nā€‰=ā€‰3).

From: Co-delivery of paclitaxel and tetrandrine via iRGD peptide conjugated lipid-polymer hybrid nanoparticles overcome multidrug resistance in cancer cells

Cells

Drugs

IC50 values (Ī¼M)

Reversal index

CI values at IC50

A2780

PTX

1.78

ā€”

Ā 

A2780/PTX

PTX

86.4

ā€”

Ā 
Ā 

TET

45.1

ā€”

Ā 
Ā 

P/T (1/0.5)

28.5/14.25

3.03

0.64

Ā 

P/T (1/1)

14.7/14.7

5.87

0.49

Ā 

P/T (1/1.5)

11.6/17.4

7.44

0.52

Ā 

P/T (1/2)

10.8/21.6

8

0.60

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