Figure 1: Tissue histology, HPV and mutation detection.
From: Genetic Mutation and Exosome Signature of Human Papilloma Virus Associated Oropharyngeal Cancer
(a) Histopathological analysis of the normal and cancer tissues by Hematoxylene and Eosine staining. HPV-16-E7 protein was detected (arrowheads) by immunohistochemistry using a specific antibody as described under the material and method section (a). Image magnification X 200. (b) The total number of somatic non-synonymous, synonymous and frameshift mutations from the coding regions of the HPVOPC subject. (c) The overall number of somatic mutations covering the coding and non coding regions of the genome. (d) Number of homozygous and heterozygous mutations observed spanning the entire genome. (e) High copy number variation in the chromosomal regions 1, 2, 3, 6, 7, 11 and 19 (arrowheads).
