Figure 4: Clusters of significant GO terms enriched with variants of different frequency. | Scientific Reports

Figure 4: Clusters of significant GO terms enriched with variants of different frequency.

From: Next-generation DNA sequencing identifies novel gene variants and pathways involved in specific language impairment

Figure 4

Enriched GO terms were identified using three gene lists marked by variant frequency (novel, less than 1%, and between 1–5%). The resulting GO terms associated with the three gene lists are colour-coded (Cyan: between 1–5%; Gold: less than 1%; Red: novel) and with size representing the number of genes within each GO term. The GO terms were clustered based on their functional similarity. Five major functional categories could be identified, namely “Extracellular Matrix Disassembly”, “Cell Proliferation in Forebrain”, “Microtubule-based Movement”, “Release of Sequestered Calcium ion into Cytosol”, and “Cellular response to interleukin-4”. Lines connecting the GO terms indicate levels of similarity between each connected pair.

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