Figure 8: MT-6 inhibits tumor growth in SKOV3 xenografted mice.
From: The apoptotic mechanisms of MT-6, a mitotic arrest inducer, in human ovarian cancer cells
(A) MT-6 reduces tumor volume in an SKOV3 xenograft model. (B) MT-6 treatment did not cause significant loss of body weight in tested animals. Mice bearing established SKOV3 tumors (~100 mm3) were injected intraperitoneally with 5 or 10 mg/kg/d of MT-6 for 50 days, and tumor volumes were measured as described in Materials and Methods (n = 6 mice/group; *P < 0.05 compared with vehicle control). (C) Effects of MT-6 on intratumoral biomarkers in SKOV3 xenograft model. Tumors were harvested at terminal sacrifice and intratumoral proteins of two representatives from each group were collected and subjected to Western blot analysis.
