Figure 2: Slc6a3 gene delivery to SN mediates the rescue of DAT protein expression. | Scientific Reports

Figure 2: Slc6a3 gene delivery to SN mediates the rescue of DAT protein expression.

From: Recombinant Adeno-Associated Virus-mediated rescue of function in a mouse model of Dopamine Transporter Deficiency Syndrome

Figure 2

Control confocal imaging of the Substantia Nigra for TH+ neurons as DA neuronal marker (magenta channel) and DAT positive cells (teal channel). (A) DAT signal is strongly evident in the case of WT animals while (B) absent in the DAT-KO mouse (scale bar 30 μm). (C) Pattern of cellular expression of the tdTOMATO protein with tyrosine hydroxylase (TH)+ cells in the SN (scale bar 50 μm). (D) Confocal imaging for the KO treated group displays co-localization of TH+ cells with DAT+ neurons (scale bar 50 μm).

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