Figure 4: Protein interaction network analysis of secreted differentially expressed proteins. | Scientific Reports

Figure 4: Protein interaction network analysis of secreted differentially expressed proteins.

From: Knockdown of stem cell regulator Oct4A in ovarian cancer reveals cellular reprogramming associated with key regulators of cytoskeleton-extracellular matrix remodelling

Figure 4

Protein interaction network generated with STRING 10.0 for, (a) cellular, (b) secretome and (c) tumor xenograft and samples. Based on molecular high-confidence action and functional enrichments analysis, major clusters of interacting proteins include those involved in regulation of actin cytoskeleton, focal adhesion, and tubulin (secretome), focal adhesion, adherenes junctions, cytoskeleton, extracellular region, and cell junction protein networks (cellular), and metabolic processes (carboxylic acid, oxoacid, carbohydrate), extracellular region, and cytoskeleton (tumor xenograft).

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