Figure 7: Proposed model of Oct4A regulation in ovarian carcinomas. | Scientific Reports

Figure 7: Proposed model of Oct4A regulation in ovarian carcinomas.

From: Knockdown of stem cell regulator Oct4A in ovarian cancer reveals cellular reprogramming associated with key regulators of cytoskeleton-extracellular matrix remodelling

Figure 7

Ovarian tumors contain high expression of Oct4A which promotes ovarian tumorigenesis27. Knockdown of Oct4A in ovarian cancer cells results in the down regulation of major regulatory network of proteins including those involved with cytoskeleton-ECM remodelling, proliferation and cellular growth, EMT, CSCs, cellular adhesion, drug resistance and cellular invasion. This promotes the diminution of tumorigenic phenotypes which we have shown in our previous studies13,27,34.

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