Table 5 Up regulated secreted proteins in HEY Oct4A KD cells.

From: Knockdown of stem cell regulator Oct4A in ovarian cancer reveals cellular reprogramming associated with key regulators of cytoskeleton-extracellular matrix remodelling

Category

Gene Name

Protein Description

Rsc

*Reference

Cytoskeletal

TUBB2C

Tubulin beta-2C

2.3

(McCarroll and Kavallaris, 2012)

TUBB4A

Tubulin beta-4 chain

2.5

(McCarroll and Kavallaris, 2012)

TUBB5

Tubulin beta-5 chain

1.7

(McCarroll and Kavallaris, 2012)

TUBB6

Tubulin beta-6 chain

2.1

(McCarroll and Kavallaris, 2012)

ACTC1

Actin, alpha cardiac muscle 1

2.3

(Tondeleir et al., 2011)

ACTB

Beta Actin

2.3

(Guo et al., 2013)

Tumour suppression

HBB

Mutant beta-globin

5.0

(Onda et al., 2005)

APOA1

Apolipoprotein A1

4.3

(Zamanian-Daryoush et al., 2013)

ITIH3

Inter-alpha-trypsin inhibitor heavy chain H3

3.3

(Paris et al., 2002)

ITIH2

Inter-alpha (Globulin) inhibitor H2

3.1

(Hamm et al., 2008)

A2M

Alpha-2-macroglobulin

3.3

(Lindner et al., 2010)

Cellular growth/survival

HSP90AA1

Heat shock protein HSP 90-alpha

2.0

(Chu et al., 2013)

SERPINE1

Plasminogen activator inhibitor

1.8

(Gomes-Giacoia et al., 2013)

HSPA8

Heat shock cognate 71 kDa protein

1.6

(Rohde et al., 2005)

HSP90AB1

Heat shock protein HSP 90-beta

1.5

(Haase and Fitze, 2015)

Oxidative stress response

GSTP1

Glutathione S-transferase P

3.3

(Kanwal et al., 2014)

HPX

Hemopexin

2.9

(Tolosano and Altruda, 2002)

HBA1

Hemoglobin subunit alpha

2.7

(Li et al., 2013c)

Prognosticator of survival

ALB

Serum albumin

4.3

(Gupta and Lis, 2010)

AFP

Alpha-fetoprotein

3.1

(Li et al., 2013a)*

Immune response

PTX3

Pentraxin-related protein PTX3

4.1

(Bonavita et al., 2015)

C4A

Complement C4-A

2.7

(Pio et al., 2013)

Cellular invasion

ANXA1

Annexin A1

4.7

(Cheng et al., 2012)

ANXA2

Annexin A2

3.3

(Lokman et al., 2013)

Estrogen-induced malignancy

SERPINA7

Thyroxine-binding globulin

4.7

(Doe et al., 1967)

Angiogenesis

APOB

Apolipoprotein B-100

3.9

(Avraham-Davidi et al., 2012)*

Apoptosis

POTEF

POTE ankyrin domain family member F

2.6

(Liu et al., 2009)

Iron transport

TF

Transferrin

2.5

(Kovac et al., 2011)

  1. Rsc: Protein abundance ratio (HEY Oct4A KD2/HEY vector control).
  2. *Supplementary File 1.