Table 1 Overview of the antibiotics and corresponding resistance genes analyzed by the different tools.

From: Mycobacterium tuberculosis resistance prediction and lineage classification from genome sequencing: comparison of automated analysis tools

 

First line drugs

Second line drugs

Tool

INH

RMP

PZA

EMB

SM

AMK

CPR

KAN

FQ

CFX

OFX

MOX

ETH

LZD

PAS

ahpC

inhA

kasA

katG

ndh

rpoB

pncA

rpsA

embA

embB

embC

embR

gidB

rpsL

rss

CASTB

?

?

?

?

?

?

?

?

?

    

     

KvarQ

 

 

 

 

   

      

Mykr. Pred. TB

 

 

 

   

   

      

PhyResSE

 

 

   

TBProfiler

 

 

 

  
  1. Unless shown by a tick, resistance antibiotics or genes are not included. Question marks were used for CASTB where it was unclear whether the genes is interrogated, as no information regarding the rules underlying the interpretation is provided for this tool. We did not list resistance genes to second-line drugs as this was beyond the scope of this study, but more information for these drugs can be found in Supplementary Table S3.