Figure 3: Analysis of proteomic data for HK-2 cells treated with TFV and ADV at 1000 μM. | Scientific Reports

Figure 3: Analysis of proteomic data for HK-2 cells treated with TFV and ADV at 1000 μM.

From: Tenofovir and adefovir down-regulate mitochondrial chaperone TRAP1 and succinate dehydrogenase subunit B to metabolically reprogram glucose metabolism and induce nephrotoxicity

Figure 3

(a) Heat map of significantly changed proteins following TFV and ADV treatments on HK-2 cells. (b) GO enrichment analysis for biological process, cell component and molecular function in HK-2 after TFV and ADV treatments. (c) The overlapped proteins between TFV and ADV treatments analyzed above. (d) Analysis of up- or down-regulated proteins with at least two unique peptides. (e) Ratio of TRAP1 in TFV and ADV treatments over controls from proteomics data. (f) Ratio of SSBP1 in TFV and ADV treatments over controls from proteomic data. (g) Significantly regulated bioenergetic proteins ACLY and GLUL ratios in TFV and ADV treatments over controls from proteomic data. Ratio was calculated as: T1/C1, T2/C1, T1/C2 and T2/C2 for TFV; A1/C1, A2/C1, A1/C2 and A2/C2 for ADV. *P < 0.05, ***P < 0.001.

Back to article page