Table 3 Subgroup analyses of tumor antigens on OS and DFS in CEA-normal CRC patients.

From: Nomograms for predicting the prognostic value of serological tumor biomarkers in colorectal cancer patients after radical resection

 

OS

DFS

Univariate analysis

P

Multivariate analysis

P

Univariate analysis

P

Multivariate analysis

P

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

Age (years)

 

0.725

   

0.776

  

 ≤60

1.000

   

1.000

   

 >60

1.113 (0.615–2.014)

   

0.942 (0.622–1.426)

   

Gender

 

0.730

   

0.148

  

 Male

1.000

   

1.000

   

 Female

1.138 (0.546–2.373)

   

0.714 (0.452–1.127)

   

Tumor location

 

0.721

   

0.846

  

 Colon

1.000

   

1.000

   

 Rectum

1.120 (0.601–2.090)

   

1.043 (0.681–1.597)

   

Tumor length (cm)

 

0.006

 

0.099

 

0.028

 

0.495

 ≤3 cm

1.000

 

1.000

 

1.000

 

1.000

 

 >3 cm

2.926 (1.360–6.295)

 

2.007 (0.877–4.594)

 

1.663 (1.056–2.618)

 

1.185 (0.728–1.927)

 

T stage

 

<0.001

 

0.035

 

<0.001

 

0.016

 T1

1.000

 

1.000

 

1.000

 

1.000

 

 T2

1.482 (0.299–7.344)

 

1.021 (0.198–5.258)

 

1.786 (0.588–5.428)

 

1.599 (0.518–4.930)

 

 T3

2.249 (0.520–9.737)

 

0.975 (0.204–4.649)

 

3.076 (1.105–8.563)

 

2.010 (0.684–5.907)

 

 T4

7.002 (1.631–30.067)

 

2.594 (0.523–12.881)

 

5.981 (2.105–16.991)

 

3.757 (1.222–11.555)

 

N stage

 

<0.001

 

0.426

 

<0.001

 

0.109

 N0

1.000

 

1.000

 

1.000

 

1.000

 

 N1

1.292 (0.592–2.820)

 

0.864 (0.367–2.035)

 

1.668 (1.014–2.743)

 

1.262 (0.732–2.175)

 

 N2

4.100 (2.083–8.068)

 

1.566(0.613–3.996)

 

3.677 (2.234–6.053)

 

1.964 (1.046–3.689)

 

Differentiation

 

0.157

   

0.227

  

 Well/Moderate

1.000

   

1.000

   

 Poor

1.848 (0.965–3.542)

   

1.458 (0.921–2.309)

   

 Unknown

1.634 (0.570–4.684)

   

0.844 (0.339–2.101)

   

Venous invasion

 

0.001

 

0.052

 

0.001

 

0.178

 Negative

1.000

 

1.000

 

1.000

 

1.000

 

 Positive

2.774 (1.500–5.127)

 

2.195 (0.993–4.855)

 

2.169 (1.384–3.398)

 

1.455 (0.843–2.510)

 

Perineural invasion

 

0.461

   

0.025

 

0.468

 Negative

1.000

   

1.000

 

1.000

 

 Positive

1.355 (0.604–3.040)

   

1.800 (1.075–3.012)

 

1.226 (0.708–2.122)

 

CA199 (U/mL)

 

0.001

 

0.194

 

0.049

 

0.449

 Normal (0–27)

1.000

 

1.000

 

1.000

 

1.000

 

 High (>27)

3.079 (1.611–5.886)

 

1.783 (0.745–4.270)

 

1.699 (1.003–2.877)

 

0.760 (0.374–1.545)

 

CA50 (IU/mL)

 

<0.001

 

0.031

 

0.001

 

0.043

 Normal (0–25)

1.000

 

1.000

 

1.000

 

1.000

 

 High (>25)

7.183 (3.024–17.060)

 

3.052 (1.105–8.430)

 

3.869 (1.787–8.378)

 

2.416 (1.027–5.686)

 

CA125 (U/mL)

 

0.292

   

0.799

  

 Normal (0–35)

1.000

   

1.000

   

 High (>35)

1.878 (0.581–6.065)

   

1.139 (0.418–3.103)

   

CA242

 

0.024

 

0.245

 

0.010

 

0.139

Normal (0–25)

1.000

 

1.000

 

1.000

 

1.000

 

High (>35)

2.146 (1.105–4.168)

 

0.972 (0.406–2.330)

 

1.885 (1.167–3.046)

 

1.614 (0.856–3.044)

 

CA724 (U/mL)

 

0.012

 

0.093

 

0.274

  

Normal (0–20)

1.000

 

1.000

 

1.000

   

High (>20)

2.392 (1.209–4.734)

 

1.828 (0.904–3.696)

 

1.362 (0.783–2.369)

   
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