Figure 9: Putative mechanism of tau hyperphosphorylation during insulin deprivation. | Scientific Reports

Figure 9: Putative mechanism of tau hyperphosphorylation during insulin deprivation.

From: Insulin deprivation induces PP2A inhibition and tau hyperphosphorylation in hTau mice, a model of Alzheimer’s disease-like tau pathology

Figure 9

STZ injection induces insulin deprivation by destroying insulin-producing cells in pancreas. The resulting T1DM lead to PP2A inhibition in the brain, which induce tau hyperphosphorylation. Insulin injection 30 minutes before sacrifice partially restores physiological phosphorylation of tau comparable to non-T1DM mice without rescue of PP2A activity, suggesting involvement of different pathway.

Back to article page