Table 1 Summary of Myostatin (Mstn) immunopositivity within the different areas of the vessel wall in the different stages of plaque progression.

Lesion Type⁶	MEDIA (VSMCs)		NEOVESSELS		INTIMA/NEOINTIMA		LESION/FIBROTIC CAP		INFILTRATING CELLS		Total case number
Lesion Type⁶	Posit.	N	Posit.	N	Posit.	N	Posit.	N	Posit.	N	Total case number
Norm	0	6	na		0	8	na		na		N = 8
Norm	+/−	2									N = 8
AIT	+/−	10	na		0	12	na		na		N = 12
AIT	+	2									N = 12
IX		3	na		0	11	na		0	12	N = 12
IX	+/++	9			+	1					N = 12
PIT	0	2	0	9	0	10	na		0	10	N = 10
	+/++	7	++	1
	++	1
EFA	0	1	0	9	0	9	0	9	0	9	N = 9
EFA	+/++	8									N = 9
LFA	+/++	3	0	3	0	1	0	3	0	3	N = 5
LFA	++	2	++	2	++	4	++	2	+	2	N = 5
TCFA	0	1	0	5	0	1	0	4	0	5	N = 8
	+/++	4	++	3	+/++	7	+/++	4	+	2
	++	3							++	1
PR	0	1	0	1	0	10	0	10	0	1	N = 10
PR	+	9	+ +	9					++	9	N = 10
HR	+	11	0	9	0	8	0	5	0	9	N = 11
HR	+	11	+++	2	+	3	+/++	6	+	2	N = 11
FCP	+/++	12	0	6	0	5	0	7	0	6	N = 12
FCP	+/++	12	+	6	+	7	+/++	5	+	6	N = 12

Values in semi-quantitative units (0: absent; +/−: low positivity; +: medium positivity; ++: high positivity; +++: the highest positive sample, as determined by 2 blind observers) and the corresponding case numbers are reported. Na: not applicable to this stage of the disease process. Norm: Normal aorta; AIT: adaptive intimal thickening; IX: Intimal xanthoma; PIT: pathological intimal thickening; EFA: Early fibroatheroma; LFA: late fibroatheroma; TCFA: thin cap fibroatheroma; PR: Plaque rupture; HR: healed plaque rupture; FCP: fibrotic calcified plaque.

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