Figure 2: S74L mutation of VP3 confers evasion from neutralization with 5H7.

Virus infection was indicated by CPE observed in inoculated Vero cells. No CPE was observed when neutralization occurred. RG: virus generated by reverse genetics; WT: wild-type virus; EM: escape mutant. 4B12: a non-neutralizing antibody against EV71 3CD; 51: a neutralizing antibody against VP1. Magnification: 100×.