Figure 9: Immunohistochemistry and histopathology of EV71-infected AG129 mice without and with therapeutic protection with 5H7. | Scientific Reports

Figure 9: Immunohistochemistry and histopathology of EV71-infected AG129 mice without and with therapeutic protection with 5H7.

From: Effective in vivo therapeutic IgG antibody against VP3 of enterovirus 71 with receptor-competing activity

Figure 9

Brain (A–D) and spinal cord (E,F) tissues were harvested and sectioned. Mice infected with a lethal dose of EV71, and treated with control antibody (A,B,E,F) displayed viral antigen and neuronal vacuolation. However, neither viral antigen nor neuronal lesion was observed in infected mice subjected to therapeutic protection with 5H7 (C,D,G,H). (B,D,F,H) Are views at higher magnification (200×) of (A,C,E and G) (40×).

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