Figure 1: In vitro immunomodulatory phenotypes of Propionibacterium freudenreichii strains grown on dairy-based culture medium. | Scientific Reports

Figure 1: In vitro immunomodulatory phenotypes of Propionibacterium freudenreichii strains grown on dairy-based culture medium.

From: Identification of proteins involved in the anti-inflammatory properties of Propionibacterium freudenreichii by means of a multi-strain study

Figure 1

Comparative anti-inflammatory (A) IL-10 and pro-inflammatory (B) IL-12, (C) IFN-γ and (D) TNF-α cytokine responses of human PBMCs stimulated by Pf strains or by the positive controls Lactococcus lactis MG1363 and Bifidobacterium longum BB536 (pro- and anti-inflammatory strains, respectively). All bacterial strains were implemented at a bacterial density corresponding to a multiplicity of infection (MOI) of 10, and the supernatants collected were analysed using ELISA. Immunocompetent PBMC cells were stimulated by bacteria for 24 h and the data are expressed in pg/ml as means +/− SEM of the results concerning four separate french healthy blood donors. The Pf strains are ordered by their decreasing induction of IL-10, which is highly variable.

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