Figure 6: Immunological consequences of the inactivation of selected genes. | Scientific Reports

Figure 6: Immunological consequences of the inactivation of selected genes.

From: Identification of proteins involved in the anti-inflammatory properties of Propionibacterium freudenreichii by means of a multi-strain study

Figure 6

Panel (A) Comparative IL-10, TNF-α, IFN-γ and IL-6 cytokine responses of human PBMCs stimulated by the two strains used as positive controls Lactococcus lactis MG1363 (pro-inflammatory) and Bifidobacterium longum BB536 (anti-inflammatory) or by two wild type Propionibacterium freudenreichii strains, CIRM 121 and CIRM 129. Panel (B) Cytokine induction by the mutant strains inactivated for the five genes positively associated with IL-10: slpB, slpE, slpF, hsdM3 and pep, expressed as a percentage of the strong anti-inflammatory wild type CIRM 129 strain. Panel C. Cytokine induction by mutant strains inactivated for eno1, htrA4, pouf8235, negatively associated with IL-10, and expressed as a percentage of the weak anti-inflammatory wild type CIRM 121 strain. Data were expressed as means +/− SEM. Symbols: *P < 0.05.

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