Figure 2: Stard7 deficiency is associated with altered mitochondrial function. | Scientific Reports

Figure 2: Stard7 deficiency is associated with altered mitochondrial function.

From: The Phosphatidylcholine Transfer Protein Stard7 is Required for Mitochondrial and Epithelial Cell Homeostasis

Figure 2

(a) Mitochondrial OCR (pMoles/min) was measured under basal conditions and in response to the indicated mitochondrial inhibitors. The OCR was lower in Stard7KDBEAS-2B cells. Transient transfection of Stard7KDBEAS-2B cells with Stard7-1HA partially restored OCR (mean ± SEM, n = 5). (b) BEAS-2B and Stard7KDBEAS-2B cells were treated with or without the indicated concentration of 3-BP or oligomycin for one hour and cellular ATP levels were determined. Data represent the averages of three independent experiments (mean ± SEM). BEAS-2B cells vs. Stard7KDBEAS-2B cells, **p = 0.0078. OCR: oxygen consumption rate. FCCP: carbonyl cyanide p-trifluoromethoxyphenylhydrazone. 3-BP: 3-bromopyruvate.

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