Table 8 Identification of MPER specific neutralizing antibodies.
Chimera | MPER Sequence@ | Neutralization | ||||||
---|---|---|---|---|---|---|---|---|
MAbs IC50*(μg/ml) | Plasma ID50 (1/dilutions) | |||||||
2F5 | 4E10 | Z13e1 | 240-D | NAB069 | NAB120 | NAB122 | ||
7312 A | NMYELQKLNSWDVFGNWFDLASWVKYIQYGVYIV | >10 | >10 | >10 | >10 | <20 | <20 | <20 |
C1 (clade B) | NMYELLALDKWASLWNWFDITKWLWYIKYGVYIV | 0.016 | 0.0017 | 0.08 | >10 | 5,074 | <20 | 2,660 |
C1C (clade C) | NMYELLALD S W KN LWNWFDITKWLWYIKYGVYIV | >10 | 0.018 | 0.07 | >10 | 12,960 | <20 | 165.5 |
C6 | NMYELQKLNSWDVFGNWFDITSWIKYIQYGVYIV | >10 | 0.013 | >10 | >10 | 2,504 | <20 | 248.1 |
C7 | NMYELQALDKWA VFGNWFDLASWVKYIQYGVYIV | 0.07 | >10 | >10 | >10 | <20 | <20 | <20 |