Figure 6: Virulence of sir2Δ in a murine model of infection.
From: Sirtuins in the phylum Basidiomycota: A role in virulence in Cryptococcus neoformans
Survival of female BALB/c mice infected with 5 × 105 cells via nasal inhalation. Four sirtuin strains were subjected to a murine model of infection, with the original sir2∆ mutant (A), a second independent sir2∆ mutant (B), and two sir2∆ mutants created in the H99O background (C) all showing attenuation compared to wild type. Kill curves were considered statistically significant from wild-type when p =< 0.05; sir2∆-1 (p =< 0.001), sir2∆-1 + SIR2 (p =< 0.001), sir2∆-2 (p =< 0.001), sir2∆-2 + SIR2 (p =< 0.001), sir2∆-3 (p =< 0.001), sir2∆-3 + SIR2 (p =< 0.001), sir2∆-3 (p =< 0.001), sir2∆-3 + SIR2_2 kb (p =< 0.001), sir2∆-4 (p =< 0.001) and sir2∆-4 + SIR2_2 kb (p =< 0.001).
