Figure 3

(a) Mutation data of the top four variant genes out of the 140 genes with available PDB structure; (b) wired model of the protein 1SJ2, Rv1908c (katG), which is a homo-2-mer, showing the major sites of mutation in the binding pocket (Mutations marked in blue; ligand HEM and co-solvent Glycerol, GOL marked in red).