Figure 1: Down-regulation of miR-26a expression is linked to proliferation of rat jugular vein VSMCs. | Scientific Reports

Figure 1: Down-regulation of miR-26a expression is linked to proliferation of rat jugular vein VSMCs.

From: MicroRNA-26a targets MAPK6 to inhibit smooth muscle cell proliferation and vein graft neointimal hyperplasia

Figure 1

(A) Representative HE staining of control (Ctrl) veins and vein grafts at 1, 2, and 4 weeks after operation. (B) Down-regulation of miR-26a expression in grafted-veins at 1, 2, and 4 weeks after autologous jugular vein graft. *P < 0.05 represents statistical significance compared to the un-grafted group. (C) Decrease in miR-26a expression induced by platelet-derived growth factor-BB (PDGF-BB; 20 ng/ml) in a dose-dependent manner in rat jugular vein SMCs as determined by quantitative reverse-transcription polymerase chain reaction (qRT-PCR) (n = 4). *P < 0.05 represents statistical significance compared to the treatment with PDGF-BB for 0 h. (D) PDGF-BB caused a time-dependent decrease in miR-26a expression in rat jugular vein VSMCs 24 h after PDGF-BB treatment, as determined by qRT-PCR (n = 4). *P < 0.05 represents statistical significance compared to treatment with 0 ng/ml PDGF-BB.

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