Figure 2: Administration of aldosterone induced podocytes injury, and FR167653 improved podocytes injury. | Scientific Reports

Figure 2: Administration of aldosterone induced podocytes injury, and FR167653 improved podocytes injury.

From: Natriuretic peptide receptor guanylyl cyclase-A pathway counteracts glomerular injury evoked by aldosterone through p38 mitogen-activated protein kinase inhibition

Figure 2

(a,b) Electron microscopic photographs of lower (a) and higher (b) magnification show that treatment with FR167653 in ALDO systemic GC-A KO mice improved GBM thickening and widening foot processes in a superficial glomerulus. Scale bar, 500 nm. (c) The width of foot processes in electron microscopic photographs. n = 3. (d,e) Representative images of nephrin (d) and podocin (e) expression by immunofluorescent study in a juxtamedullary glomerulus. Scale bar, 50 μm. ††p < 0.01, vs. ALDO wild-type mice. **p < 0.01 vs. ALDO systemic GC-A KO mice.

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