Figure 5: Administration of aldosterone aggravated podocyte injury. | Scientific Reports

Figure 5: Administration of aldosterone aggravated podocyte injury.

From: Natriuretic peptide receptor guanylyl cyclase-A pathway counteracts glomerular injury evoked by aldosterone through p38 mitogen-activated protein kinase inhibition

Figure 5

(a,b) Representative images of nephrin (a) and podocin (b) expression by immunofluorescent study in a juxtamedullary glomerulus. Scale bars, 50 μm. (c) Transmission electron microscopic microphotographs of a juxtamedullary glomerulus. ALDO pod GC-A cKO mice exhibited mild thickening GBM and foot process effacement and its injury was ameliorated with the administration of FR167653. (d) Immunohistochemical staining for phosphorylated p38 MAPK. Arrows, phospho-p38 MAPK positive cells. Scale bars, 50 μm.

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