Table 1 Body and kidney weights, and blood and urinary parameters in ALDO wild-type or ALDO systemic GC-A KO mice with or without FR167653.

From: Natriuretic peptide receptor guanylyl cyclase-A pathway counteracts glomerular injury evoked by aldosterone through p38 mitogen-activated protein kinase inhibition

 

ALDO WT

ALDO WT + FR

ALDO KO

ALDO KO + FR

BW at 4 wk, g

29.1 ± 0.4

29.1 ± 0.5

28.9 ± 0.8

28.0 ± 0.5

LKW at 4 wk, mg

312 ± 13

322 ± 16

396 ± 7††

364 ± 16

LKW/BW at 4 wk, mg/g

10.75 ± 0.64

11.07 ± 0.62

13.70 ± 0.44††

13.04 ± 0.84

Serum UN, mg/dL

23.9 ± 1.9

23.9 ± 1.3

23.5 ± 3.4

24.0 ± 1.9

Serum Cr, mg/dL

0.142 ± 0.012

0.166 ± 0.017

0.166 ± 0.029

0.170 ± 0.008

Serum sodium, mEq/L

162.2 ± 1.0

160.4 ± 0.9

162.6 ± 1.3

160.2 ± 1.5

Serum potassium, mEq/L

3.02 ± 0.21

3.46 ± 0.12

3.10 ± 0.10

3.36 ± 0.22

Urinary sodium, mEq/day

2.26 ± 0.39

1.90 ± 0.09

2.87 ± 0.41

2.50 ± 0.28

Urinary potassium, mEq/day

0.49 ± 0.06

0.54 ± 0.08

0.69 ± 0.07

0.62 ± 0.04

Urinary potassium/sodium

0.246 ± 0.023

0.273 ± 0.020

0.237 ± 0.029

0.251 ± 0.019

Urinary albumin, ÎĽg/mgCr

73.9 ± 9.5

39.0 ± 4.0

9,268 ± 737††

580 ± 99**

  1. BW, body weights; LKW, left kidney weights; UN, urea nitrogen; Cr, creatinine.
  2. Values are expressed as the mean ± SEM for aldosterone-infused and high salt diet-fed uninephrectomized (ALDO) wild-type mice (ALDO WT; n = 5), ALDO wild-type mice with FR167653 (ALDO WT + FR; n = 5), ALDO systemic GC-A KO mice (ALDO KO: n = 5), ALDO systemic GC-A KO mice with FR167653 (ALDO KO + FR; n = 5).
  3. ††p < 0.01, ALDO WT vs. ALDO KO.
  4. **p < 0.01, ALDO KO vs. ALDO KO + FR.
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