Table 2 Body and kidney weights, and blood and urinary parameters in VEH or ALDO control or pod-GC-A cKO mice.

From: Natriuretic peptide receptor guanylyl cyclase-A pathway counteracts glomerular injury evoked by aldosterone through p38 mitogen-activated protein kinase inhibition

 

VEH cont.

ALDO cont.

VEH cKO

ALDO cKO

ALDO cKO + FR

BW at 4 wk, g

29.9 ± 0.3

30.1 ± 0.5

29.2 ± 0.3

30.2 ± 0.4

30.0 ± 0.5

LKW at 4 wk, mg

245 ± 6

304 ± 12††

241 ± 6

322 ± 9**

337 ± 10

LKW/BW at 4 wk, mg/g

8.23 ± 0.18

10.14 ± 0.54††

8.24 ± 0.16¶¶

10.67 ± 0.35**

11.24 ± 0.38

Serum UN, mg/dL

37.8 ± 1.9

36.3 ± 2.9

41.35 ± 1.4

30.65 ± 2.2*

24.5 ± 1.5

Serum Cr, mg/dL

0.168 ± 0.006

0.196 ± 0.019

0.181 ± 0.008

0.147 ± 0.012

0.147 ± 0.009

Serum sodium, mEq/L

154.1 ± 1.3

160.0 ± 0.9

156.4 ± 1.2

158.1 ± 0.8

159.8 ± 0.6

Serum potassium, mEq/L

4.43 ± 0.12

3.76 ± 0.24

4.67 ± 0.09

3.54 ± 0.23*

3.57 ± 0.10

Urinary sodium, mEq/day

3.00 ± 0.18

3.28 ± 0.31

3.10 ± 0.22

3.58 ± 0.31

3.40 ± 0.23

Urinary potassium, mEq/day

0.62 ± 0.03

0.71 ± 0.07††

0.58 ± 0.04

0.83 ± 0.08**

0.71 ± 0.03

Urinary potassium/sodium

0.211 ± 0.005

0.222 ± 0.015

0.188 ± 0.004

0.246 ± 0.032

0.212 ± 0.010

Urinary albumin, ÎĽg/mgCr

31.3 ± 3.6

84.0 ± 6.5†, ¶¶

40.2 ± 9.7

1,188 ± 152**

80.5 ± 10.5¶

  1. BW, body weights; LKW, left kidney weights; UN, urea nitrogen; Cr, creatinine.
  2. Values are expressed as the mean ± SEM for vehicle-infused high salt fed uninephrectomized (VEH) control mice (VEH cont.; n = 7), ALDO control mice (ALDO cont.; n = 7), VEH pod GC-A cKO mice (VEH cKO: n = 7), ALDO pod GC-A cKO mice (ALDO cKO; n = 7), ALDO pod GC-A cKO mice with FR167653 (ALDO cKO + FR; n = 7).
  3. †p < 0.05, ††p < 0.01, VEH cont. vs. ALDO cont.
  4. *p < 0.05, **p < 0.01, VEH pod GC-A cKO vs. ALDO pod GC-A cKO.
  5. ¶p < 0.05, ¶¶p < 0.01, vs. ALDO pod GC-A cKO.
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