Figure 3: Scheme of short-, long- and very long-chain fatty acid biosynthesis leading to membrane phospholipids synthesis. | Scientific Reports

Figure 3: Scheme of short-, long- and very long-chain fatty acid biosynthesis leading to membrane phospholipids synthesis.

From: Metabolism dysregulation induces a specific lipid signature of nonalcoholic steatohepatitis in patients

Figure 3

The long chain saturated fatty acids and unsaturated fatty acids of the n-3, n-6, n-7 and n-9 series can be synthesized from myristic acid (C14:0) and palmitic acid (C16:0) produced by ACC and FASN. Long-chain fatty acids of the n-6 and n-3 series can also be synthesized from precursors obtained from dietary precursors to elongation (ELOVL) and desaturation (FADS) steps as indicated in these pathways. Lipids in red and in green are those found “up” and “down” in our analysis, respectively. Increase in enzyme activities is framed in red whereas a decrease is framed in green. ACC: acetyl-CoA carboxylase; ELOVL: elongase of very long chain fatty acid; FASN: fatty acid synthase; FADS: fatty acid desaturase; SCD: stearoyl-CoA desaturase.

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