Figure 4: Decrease in ELOVL 6 and FADS1 activities in NASH patients and mouse feeding a methionine-choline deficient diet. | Scientific Reports

Figure 4: Decrease in ELOVL 6 and FADS1 activities in NASH patients and mouse feeding a methionine-choline deficient diet.

From: Metabolism dysregulation induces a specific lipid signature of nonalcoholic steatohepatitis in patients

Figure 4

In order to evaluate enzyme activities, ratio between product to precursor of each reaction has been used in human groups (left panel) and mouse models (right panel). (a) Evaluation of ELOVL5 activity using C20:2n-6 to C18:2n-6 ratio, (b) ELOVL6 activity using C18:0 to C16:0 ratio, (c) FADS2 activity using C18:3n-3 to C18:2n-6 ratio, (d) SCD1 activity using C16:1 to C16:0 ratio and (e) FADS1 activity using C20:4n-6 to C20:3n-6 ratio. Data are shown as mean ± SEM. *p < 0.05 by unpaired t-test compared to each other groups. +<0.05 by unpaired t-test compared to Control and §p < 0.05 by unpaired t-test compared to Control. NAFL1 and NAFL2 after ANOVA analysis. Control patients n = 7; NAFL1 n = 9; NAFL2 n = 12; NAFL3 n = 18; NASH_Lds n = 15; NASH_Vds n = 7. Control mice n = 10; HFD n = 5; MCDD n = 5.

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