Figure 6: Clearance and tissue localization of 125I-β2m in β2m knock out mice. | Scientific Reports

Figure 6: Clearance and tissue localization of 125I-β2m in β2m knock out mice.

From: A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo

Figure 6

(a) Clearance of 125I-D76N β2m in groups of four mice (strain B6.129P2-B2mtm1Unc/J) receiving intravenously the protein either alone or in a 1:1 complex with Nb24. Clearance is not modified in the presence of the complex. (b) Localization of 125I-D76N β2m in tissues after 180 min. Mice treated with the complex have less radioactivity in the heart. (c) Clearance and (d) tissue localization of 125I-wild type β2m in groups of four mice (strain B6.129P2-B2mtm1Unc/J) receiving either the protein alone or in an equimolar complex with Nb24. Data expressed as cpm/gr represent mean ± SD of four mice per group. *P < 0.05 according to Kruskal-Wallis test followed by post-hoc Dunn’s test. 125I-D76N β2m alone, black; 125I-D76N β2m/Nb24, red; 125I-wild type β2m alone, blue; 125I-wild type β2m/Nb24, cyan.

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