Table 2 Influential variables from the placebo and sertraline models

Var ID	Placebo VIP	Compound	Var ID	Sertraline VIP	Compound
	R vs NR			R vs NR
15-16.625	2.99496	HX^a	3-65.475	2.82796
14-12.675	2.52897		8-55.65	2.45127
14-13.4	2.47942		8-46.25	2.37137
3-10.05	2.37731	URIC^a	9-95.25	2.28433
8-86.925	2.32235		11-83.4	2.26306
8-16.225	2.30022		1-12.45	2.1625
15-84.375	2.27326		14-51.375	2.15344
7-16.2	2.24651	VMA^b	1-65.375	2.09615
9-86.95	2.21169		12-5.925	2.03472
9-62.825	2.12136		1-20.2	2.00379
9-62.825	2.12136		10-9.85	2.00041
15-95.825	2.11767		3-37.15	1.89479	DOPAC^b
10-35.525	2.11097		11-38.15	1.62464	4-HPLA^b
15-87.275	2.10836		5-58.425	1.40038	5-HT^c
10-86.975	2.07774		7-103.175	1.19178	GTOCO^d
8-71.5	2.01329		4-104.6	1.0539	TOCO^d
3-22.6	1.92119	HGA^b
11-64.6	1.91157	5-MTPOL^c
11-73.5	1.69416	IAA^c
6-7.9	1.65127	ASC
8-23.8	1.54448	MHPG2
7-101.45	1.52418	DTOCO^d
1-35.325	1.49646	3-OHKY^c
7-103.175	1.31534	GTOCO^d
16-11.325	1.30019	CYS^e
3-37.15	1.25549	DOPAC^b
5-58.425	1.24512	5-HT^c
12-12.9	1.18595	XAN^a
3-45.425	1.06467	5-HIAA^b
4-104.6	1.02822	TOCO^d
3-28.05	1.01075	LD^b

Abbreviations: ASC, ascorbate; CYS, cysteine; DOPAC, dihydroxyphenylacetic acid; DTOCO, delta tocopherol; GTOCO, tocopherol-gamma; HGA, homogentisic acid; 5-HIAA, 5-hydroxyindoleacetic acid; 4-HPLA, 4-hydroxyphenyllactic acid; 5-HT, serotonin; HX, hypoxanthine; IAA, indoleacetic acid; LD, L-dopa; MHPG, methoxy-hydroxyphenly glycol; MTPOL, 5-methoxytryptophol; 3-OHKY, 3-hydroxykynurenine; TOCO, tocopherol; URIC, uric acid; VIP, variable influence on the projection; VMA, vanillylmandelic acid; XAN, xanthine.
Note: only unknown variables with VIPs >2 are included in this table. All known variables with a VIP>1 are included.
Note: the blue color indicates VIPs that are in common in the sertraline and placebo models.
^aPurine pathway metabolite.
^bTyrosine pathway metabolite.
^cTryptophan pathway metabolite.
^dBiosynthesis of steroids.
^eCysteine.

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