Figure 4

Three-dimensional (3D) surface images showing global brain single-photon emission computed tomography (SPECT) decreases in suicide cohort versus depressed non-suicidal cohort. Cortical surface views show diffuse regions of decreased regional cerebral blood flow in suicide subjects at P<1 × 10−5, family-wise error (FWE) in comparison to non-suicidal subjects with matched diagnostic profiles. Significant decreases are in blue. No increases were observed.