Figure 3
From: Increased de novo copy number variants in the offspring of older males
CNV2 details. (a) Array log(2) signal intensity ratios of the individual probes are plotted along mouse chromosome 5 and connected with a trend line based on triangular smoothening. A de novo deletion (CNV2) affecting the Auts2 gene was detected in one female offspring of an old sire. The two purple lines depict the result of a technical replicate with the animal containing the deletion. The black line visualizes the result obtained from a self-hybridization array, which was used to control for noise. The location of the CNV on the mouse genome is boxed. (b) CNV2 was aligned to the human genome using the UCSC genome browser (http://genome.ucsc.edu/) together with copy variants observed in the human and genomic regions associated with neurocognitive disease. HapMap: Case from the International Hapmap Project. SLEP, Sullivan Laboratory Evidence Project; CNV, copy number variant; DEL, deletion; AMP, amplification; DN, de novo.
