Figure 3
From: Interactions of human truncated DISC1 proteins: implications for schizophrenia
Predicted binding sites of truncated DISC1 proteins. A diagram showing binding sites of full-length DISC1 (L) protein with NDEL1, PDE4B, GSK3β, FEZ1 and DISC1 self-association sites as determined by previous studies.14, 9, 4, 10, 21, 15 Black rectangles indicate areas of coiled coil-forming potential, and the dotted line signifies the translocation breakpoint of the Scottish family translocation. Shown below the full-length DISC1 form is a representation of the protein isoforms translated from novel variants DISC1 LΔ3, LΔ78T9, Esv1. In parenthesis, the source sequence of the transcript is listed according to the April 2011 version of the NCBI database. Along with exon deletions that may disrupt protein interactions, the short isoforms may lose C-terminus-binding sites.
