Figure 1 | Translational Psychiatry

Figure 1

From: Enriched environment treatment reverses depression-like behavior and restores reduced hippocampal neurogenesis and protein levels of brain-derived neurotrophic factor in mice lacking its expression through promoter IV

Figure 1

Effect of enriched environment (EE) on depression-like behavior in brain-derived neurotrophic factor knock-in IV (BDNF-KIV) and wild-type (WT) mice. (a) The open-field test measuring total locomotor activity of mice for 10 min. Note that KIV-standard condition (SC) (BDNF-KIV mice in standard condition) showed reduced locomotor activity compared with WT-SC (WT mice in SC), while KIV-EE (BDNF-KIV mice in enriched environment) as well as WT-EE (WT mice in EE) showed similar locomotor activity compared to WT-SC (n=12 per group). (b) The tail suspension test measuring immobility time of mice for 6 min. Note the increased immobility time in KIV-SC but similar immobility time in KIV-EE compared with WT-SC. (n=12 per group). (c) The sucrose preference test measuring % sucrose preference (total intake of sucrose water/total liquid intake of sucrose water and water) of mice over 3 h. The 50% dotted line is shown to indicate the equal preference for water and sucrose. Note that KIV-SC showed reduced sucrose preference compared with WT-SC, while KIV-EE as well as WT-EE showed sucrose preference similar to WT-SC (n=8 per group). Results are expressed as mean±s.e. *P<0.05; **P<0.01.

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