Figure 1

(a) Prefrontal cortex regions exhibiting greater activation to negative words than neutral in the NAC group (red), lesser activation to negative words than neutral in the GAD group (green) and greater negative>neutral contrast values in the NAC group than in the GAD group (yellow). Middle panel shows overlapping red and yellow clusters. Images are displayed in neurological convention (right=right). All voxels shown are significant at P<0.005, uncorrected and P<0.05, corrected. (b) Surface rendering of the regions shown in panel a. Image is shown in radiological convention (left=right). NAC, non-anxious control; GAD, generalized anxiety disorder.