Table 3 Pathway analysis of metabolomics data from the GC × GC–TOFMS platform

KEGG ID	Pathway name	Size	P-MCI versus S-MCI				AD versus controls
			N/N _all	*Medium-K*	P	P _corr	N/N _all	*Medium-K*	P	P _corr
map00030	Pentose phosphate pathway	28	2/(32)	2	0.000130	0.09	15/(434)	3	0.000580	0.46
map00051	Fructose and mannose metabolism	28	18/(466)	2	0.017702	0.91	10/(281)	2	0.007617	0.43
map00052	Galactose metabolism	33	18/(466)	2	0.024189	0.93	14/(359)	2	0.054227	0.50
map00061	Fatty acid biosynthesis	48	19/(489)	3	0.005718	0.99	19/(538)	2	0.019644	0.99
map00520	Amino sugar and nucleotide sugar metabolism	66	18/(466)	2	0.085056	0.87	4/(159)	2	0.002265	0.71
map00710	Carbon fixation in photosynthetic organisms	22	18/(466)	2	0.011108	0.91	18/(511)	3	0.004883	0.82
map01040	Biosynthesis of unsaturated fatty acids	48	19/(489)	3	0.005718	0.99	15/(434)	2	0.007750	0.63
map01100	Metabolic pathways	1059	7/(120)	3	0.661475	0.25	15/(434)	3	0.986924	0.91
map01110	Biosynthesis of secondary metabolites	472	5/(81)	2	0.253492	0.15	15/(434)	3	0.585593	0.60

‘KEGG ID’ is the KEGG identifier of the pathway, ‘Pathway name’ is the name of the pathway given by KEGG and ‘Size’ is the number of metabolites that belong to a particular pathway. ‘Medium-K’ is the number of metabolites within the data set assigned to the pathway, after pathway inconsistencies has been corrected, and ‘N/N_all’ is the rank at which the minimum P-value was obtained using features associated to KEGG (N) and all features (N_all), respectively. P is the P-value given by hypergeometric distribution and P_corr is the corresponding permutation-corrected P-value.
P-values for P_corr<0.1 marked in bold.

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