Figure 1 | Translational Psychiatry

Figure 1

From: Metabolite profiling of antidepressant drug action reveals novel drug targets beyond monoamine elevation

Figure 1

Behavioral analysis of paroxetine-treated mice. (a) Chronic paroxetine treatment reduced passive behavior in the forced swim test determined by time of floating, P<0.0001, tfloating (vehicle)=90.3±6.1 s (mean±s.e.m.), tfloating (paroxetine)=20.6±4.2 s. (b) Six biological replicates were selected for metabolomics analysis based on the time of floating, P=0.0014, tfloating (vehicle)=97.0±11.0 s (mean±s.e.m.), tfloating (paroxetine)=22.7±12.9 s.

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