Table 2 Antidepressant drug target candidates that are regulators and targets of altered metabolites, expression analysis systematic explorer (EASE), score<0.05
Pathway cluster | Antidepressant drug target candidate | Category | P -value | EASE score |
|---|---|---|---|---|
Carbohydrate metabolism | ATP-dependent hexokinase | Functional class | 0.005 | 0.033 |
| Â | D-fructose 1,6-diphosphatase | Functional class | 4.1E-04 | 0.012 |
| Â | FBP1 (fructose bisphosphatase 1) | Protein | 0.004 | 0.042 |
| Â | GCK (glucokinase) | Protein | 8.8E-05 | 0.001 |
| Â | glucose transporter | Functional class | 0.002 | 0.021 |
| Â | GYS2 (glycogen synthase 2) | Protein | 0.001 | 0.008 |
| Â | HK1 (hexokinase 1) | Protein | 1.5E-04 | 0.006 |
| Â | HK2 (hexokinase 2) | Protein | 7.5E-05 | 0.004 |
| Â | MPI (mannose phosphate isomerase) | Protein | 1.5E-04 | 0.006 |
Amino acid metabolism | 3-Methyl-2-oxobutanoate dehydrogenase | Functional class | 0.002 | 0.033 |
| Â | aa (amino acid) import | Cellular process | 0.005 | 0.048 |
| Â | Glutamate dehydrogenase | Functional class | 0.004 | 0.030 |
Hormone signaling | AGT (angiotensinogen) | Protein | 0.012 | 0.047 |
| Â | DPP4 (dipeptidyl-peptidase 4) | Protein | 1.5E-04 | 0.006 |
| Â | GCG (glucagon) | Protein | 0.004 | 0.021 |
| Â | INS (insulin) | Protein | 0.003 | 0.013 |
Other | Uchl1 (ubiquitin carboxyl-terminal esterase L1) | Protein | 0.002 | 0.032 |
